Title: Stem Cell Systems: Interplay Between Complex Data and Models
Speaker: Qing Nie (University of California, Irvine)
Abstract: In developing and renewing tissues, terminally differentiated cell types are typically specified through the actions of multistage cell lineages. Such lineages commonly include stem cells and multiple progenitor cell stages, which ultimately give rise to terminally differentiated cells. In this talk, I will present several modeling frameworks with different complexity on multistage cell lineages driven by stem cells, which account for diffusive signaling molecules, regulatory networks, individual cells, mechanics, and evolution. Questions of our interest include role of feedbacks, stem cell niche for spatial organization, crosstalk between epigenetic and gene regulations, and cellular plasticity. In particular, I will discuss our recent effort on connecting modeling and complex experimental data to elucidate principles for stem cell dynamics in development and regeneration.
Seminar URL: https://people.math.osu.edu/xue.41/AppliedMathSeminar.html